At The Blackwell Clinic, our polynucleotides use next-generation regenerative biotechnology to restore skin vitality, improve elasticity, and encourage healthy hair growth. PDRN supports cell regeneration and skin elasticity. Our polynucleotides are Plinest by Mastelli, XDNA by Mesoestetic alongside high concentration PDRN and Polynucleotide injections from Korean skincare line LeVair.
These innovative injectable bio stimulators activate your body’s natural repair processes, enhancing collagen, hydration, and cellular renewal from within, without adding volume or altering facial structure.
Whether you’re targeting fine lines, under-eye hollows, acne-prone skin, or early-stage hair loss, polynucleotide injections offers a subtle yet powerful route to long-term rejuvenation.
Polynucleotides and PDRN are purified DNA fragments derived from safe, biocompatible sources (such as salmon DNA). Once injected into the skin or scalp, they act as bio-stimulators, improving cell communication and restoring the integrity of the tissue matrix.
They help to:
Because they are non-volumising, polynucleotides deliver a natural, fresh-faced look rather than a “filled” appearance.
Our polynucleotide skin booster protocols focus on repairing and revitalising tired, dull, or crepey skin. Treatments can be used on the face, under-eyes, neck, décolletage, and even hands.
Best suited for:
Under-eye skin is thin and delicate, often the first area to show tiredness or ageing. Polynucleotides under the eyes strengthen this area by improving microcirculation and stimulating collagen while reducing puffiness and pigmentation. The outcome is a smoother, brighter eye contour with less visible fine lines and shadows.
Our newest product in clinic is Korean skincare line – LeVair The Eye Revive PN Booster which combines polynucleotides and Botulinum peptides; to target dark circles, reduce wrinkles, boost elasticity and improve volume.
Polynucleotides for hair loss are designed to rejuvenate the scalp environment, making it healthier and more conducive to hair growth.
This treatment helps with:
By enhancing the extracellular matrix and blood flow around hair follicles, the treatment encourages stronger, denser hair regrowth. It can be used alone or combined with PRP or mesotherapy for enhanced results.
| Feature | Polynucleotides | Profhilo |
|---|---|---|
|
Composition |
DNA fragments for cellular repair
|
Hyaluronic acid for hydration |
|
Mechanism |
Stimulates fibroblasts, collagen, and elastin |
Spreads through skin to hydrate and firm |
|
Effect |
Regenerates and strengthens skin from within |
Plumps and smooths surface lines |
|
Use areas |
Skin, scalp, and under-eyes |
Face, neck, hands |
|
Ideal for |
Repair, inflammation control, skin regeneration |
Hydration and elasticity |
Immediately after treatment, mild redness or swelling may occur but subsides within 24–48 hours.
Over the next 3–6 weeks, gradual improvements in texture, firmness, and radiance become visible as collagen production increases.
Full results continue developing for up to 3 months and can last 6–9 months, depending on lifestyle and skincare habits.
| Aspect | Details |
|---|---|
|
Time required |
30–45 minutes per session
|
|
Time until results |
3–6 weeks, building over time |
|
Longevity |
6–9 months with maintenance |
|
Number of treatments |
3–4 spaced 2–4 weeks apart |
|
Anaesthetic required |
Topical numbing cream for comfort |
|
Suitable for |
All skin types, including sensitive skin |
Your practitioner will assess your suitability and develop a tailored plan during your consultation.
Polynucleotides improve skin quality rather than volume. They rebuild structure and hydration over time, while fillers add immediate volume to restore facial contours.
Yes. They are derived from highly purified, medical-grade sources with strong clinical evidence for safety and efficacy.
Minimal. Expect mild redness or swelling at injection points for up to 48 hours.
Initial improvements appear after 2–3 weeks, with continued regeneration for several months.
Absolutely. They complement microneedling, PRP, and laser rejuvenation beautifully.
Complications are extremely rare when performed by qualified medical professionals. Improper technique or unverified products may cause temporary swelling or uneven results hence why treatment should always be done in a medical clinic setting.
Compliant Statement: All injectable treatments are administered only after a medical consultation. Results vary per individual. The Blackwell Clinic complies with UK advertising and prescription guidelines for non-surgical medical treatments.
